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热烈祝贺欣博盛最新代理法国Lunginnov 公司产品！
716 人阅读发布时间：2012-01-09 10:30
Lunginnov公司主要开发，生产和销售多种产品，包括ENDOCAN的生物标志物。“LUNGINNOV”这个名称的由来是因为Endocan/ ESM-1最初是在激活的肺内皮细胞中发现的。现阶段我们知道 endocan/ ESM-1 是可以在许多器官中检测血管内皮功能障碍 的生物标志物。
Endocan(又称內皮细胞特异性分子1，Esm-1)是一种分子量约50 kDa的可溶性蛋白多糖, 由核心蛋白和一条condroitin/ dermatan sulfate（CS/DS）糖链组成，主要表达于人体肺、肾组织及內皮细胞中。研究表明，內皮细胞的endocan会受周围环境因子的调控；如炎症反应时大量表达的细胞因子TNF-alpha及促进细胞增殖、血管新生的生长因子VEGF-A等。之前体外实验证实，endocan可与肝细胞生长因子HGF/ SF协同作用，通过其糖链增强HGF/SF促进细胞增殖的能力。也有文献指出，在老鼠体內移植稳定表达endocan的HEK293细胞后，可观察到肿瘤生成现象；其中核心蛋白氨基酸F115-116序列及糖基链对于endocan促进肿瘤生长的功能十分重要。临床研究也发现，在许多癌症 及败血休克 病人的血液中均可检测到高水平表达的endocan, 其表达量与癌症病人的预后不良及血管新生现象密切相关，因而推测endocan可做为肿瘤严重程度的指标。
| 编号 | 名称 | 应用 | 规格 |
| 抗体 | |||
| LIA-0901 | Anti-human Endocan / ESM-1 Antibody (N-Ter) MEP08 | IHC | 100 µg |
| LIA-0901S | Anti-human endocan / ESM-1 antibody (N-Ter) MEP08 | IHC | 20 µg |
| LIA-0901B | Anti-human endocan clone / ESM-1 Antibody MEP08 biotinylated | - | 20 µg |
| LIA-0902 | Anti-human Endocan / ESM-1 Antibody (N-Ter) MEP21 | Western Blot | 100 µg |
| LIA-0902S | Anti-human endocan / ESM-1 antibody (N-Ter) MEP21 | Western Blot | 20 µg |
| LIA-0905 | Anti-mouse Endocan / ESM-1 Antibody (N-Ter) GGR222 | WB, IHC | 100 µg |
| LIA-0905S | Anti-mouse Endocan / ESM-1 Antibody (N-Ter) GGR222 | WB, IHC | 20 µg |
| LIA-0905B | Anti-mouse Edocan / ESM-1 Antibody biotinylated | - | 20 µg |
| LIA-1001 | Anti-human/mouse/rat Endocan Antibody (C-ter) MEP14 | WB, IHC, ELISA | 100 µg |
| LIA-1001S | Anti-human Endocan / ESM-1 Antibody (C-Ter) MEP14 | WB, IHC, ELISA | 20 µg |
| LIA-1002 | Anti-human Endocan / ESM-1 Antibody (N-Ter) MEC 15 | WB, ELISA, FACS | 100 µg |
| LIA-1002S | Anti-human Endocan / ESM-1 Antibody (N-Ter) MEC 15 | WB, ELISA, FACS | 20 µg |
| LIA-1002B | Anti-human Endocan / ESM-1 Antibody MEC15 biotinylated | ELISA | 20 µg |
| LIA-1003 | Anti-human Endocan / ESM-1 Antibody (C-Ter) MEP19 | IP | 100 µg |
| LIA-1003S | Anti-human Endocan / ESM-1 Antibody (C-Ter) MEP19 | IP | 20 µg |
| LIA-1101 | Anti-mouse Endocan / ESM-1 Antibody (Internal) GGR237 | IP | 100 µg |
| LIA-1101S | Anti-mouse Endocan / ESM-1 Antibody (Internal) GGR237 | IP | 20 µg |
| LIA-1001B | Anti-mouse Endocan / ESM-1 Antibody (Internal) GGR237 biotinylated | ELISA | 20 µg |
| ELISA 试剂盒 | |||
| LIK-1101 | Human endocan / ESM-1 DIY (Do it yourself) ELISA Kit | ELISA | 2x96 wells |
| LIK-1102 | Murine endocan / ESM-1 DIY (Do it yourself) ELISA Kit | ELISA | 2x96 wells |
| LIK-1103 | Rat endocan / ESM-1 DIY (Do it yourself) ELISA Kit | ELISA | 2x96 wells |
| 重组蛋白 | |||
| LIP-1001-10U | Human recombinant Endocan / ESM-1 50 kDa (10 µg) | Bioassay, WB | 10 µg |
| LIP-1001-50U | Human recombinant Endocan / ESM-1 50 kDa (50 µg) | Bioassay, WB | 50 µg |
| LIP-1002-10U | Human recombinant Endocan / ESM-1 20 kDa (10 µg) | Bioassay, WB | 10 µg |
| LIP-1002-50U | Human recombinant Endocan / ESM-1 20 kDa (50 µg) | Bioassay, WB | 50 µg |
| LIP-1003-10U | Mouse recombinant Endocan / ESM-1 50 kDa (10 µg) | Bioassay, WB | 10µg |
| LIP-1003-50U | Mouse recombinant Endocan / ESM-1 50 kDa (50 µg) | Bioassay, WB | 50 µg |
| LIP-1102-10U | Mouse recombinant Endocan / ESM-1 20 kDa (10 µg) | Bioassay, WB | 10 µg |
| LIP-1102-50U | Mouse recombinant Endocan / ESM-1 20 kDa (50 µg) | Bioassay, WB | 50 µg |
| LIP-1104 | Standard Murine endocan | ELISA | 100 ng |
| LIP-1101 | Standard human Endocan | ELISA | 100 ng |
| LIDS-1001-10U | Dermatan sulfate chains from recombinant human endocan 10 µg | Bioassay | 10 µg |
| LIDS-1001-50U | Dermatan sulfate chains from recombinant human endocan 50 µg | Bioassay | 50 µg |
| 编号 | 名称 | 应用 | 规格 |
| 抗体 | |||
| LIA-0901 | Anti-human Endocan / ESM-1 Antibody (N-Ter) MEP08 | IHC | 100 µg |
| LIA-0901S | Anti-human endocan / ESM-1 antibody (N-Ter) MEP08 | IHC | 20 µg |
| LIA-0901B | Anti-human endocan clone / ESM-1 Antibody MEP08 biotinylated | - | 20 µg |
| LIA-0902 | Anti-human Endocan / ESM-1 Antibody (N-Ter) MEP21 | Western Blot | 100 µg |
| LIA-0902S | Anti-human endocan / ESM-1 antibody (N-Ter) MEP21 | Western Blot | 20 µg |
| LIA-0905 | Anti-mouse Endocan / ESM-1 Antibody (N-Ter) GGR222 | WB, IHC | 100 µg |
| LIA-0905S | Anti-mouse Endocan / ESM-1 Antibody (N-Ter) GGR222 | WB, IHC | 20 µg |
| LIA-0905B | Anti-mouse Edocan / ESM-1 Antibody biotinylated | - | 20 µg |
| LIA-1001 | Anti-human/mouse/rat Endocan Antibody (C-ter) MEP14 | WB, IHC, ELISA | 100 µg |
| LIA-1001S | Anti-human Endocan / ESM-1 Antibody (C-Ter) MEP14 | WB, IHC, ELISA | 20 µg |
| LIA-1002 | Anti-human Endocan / ESM-1 Antibody (N-Ter) MEC 15 | WB, ELISA, FACS | 100 µg |
| LIA-1002S | Anti-human Endocan / ESM-1 Antibody (N-Ter) MEC 15 | WB, ELISA, FACS | 20 µg |
| LIA-1002B | Anti-human Endocan / ESM-1 Antibody MEC15 biotinylated | ELISA | 20 µg |
| LIA-1003 | Anti-human Endocan / ESM-1 Antibody (C-Ter) MEP19 | IP | 100 µg |
| LIA-1003S | Anti-human Endocan / ESM-1 Antibody (C-Ter) MEP19 | IP | 20 µg |
| LIA-1101 | Anti-mouse Endocan / ESM-1 Antibody (Internal) GGR237 | IP | 100 µg |
| LIA-1101S | Anti-mouse Endocan / ESM-1 Antibody (Internal) GGR237 | IP | 20 µg |
| LIA-1001B | Anti-mouse Endocan / ESM-1 Antibody (Internal) GGR237 biotinylated | ELISA | 20 µg |
| ELISA 试剂盒 | |||
| LIK-1101 | Human endocan / ESM-1 DIY (Do it yourself) ELISA Kit | ELISA | 2x96 wells |
| LIK-1102 | Murine endocan / ESM-1 DIY (Do it yourself) ELISA Kit | ELISA | 2x96 wells |
| LIK-1103 | Rat endocan / ESM-1 DIY (Do it yourself) ELISA Kit | ELISA | 2x96 wells |
| 重组蛋白 | |||
| LIP-1001-10U | Human recombinant Endocan / ESM-1 50 kDa (10 µg) | Bioassay, WB | 10 µg |
| LIP-1001-50U | Human recombinant Endocan / ESM-1 50 kDa (50 µg) | Bioassay, WB | 50 µg |
| LIP-1002-10U | Human recombinant Endocan / ESM-1 20 kDa (10 µg) | Bioassay, WB | 10 µg |
| LIP-1002-50U | Human recombinant Endocan / ESM-1 20 kDa (50 µg) | Bioassay, WB | 50 µg |
| LIP-1003-10U | Mouse recombinant Endocan / ESM-1 50 kDa (10 µg) | Bioassay, WB | 10µg |
| LIP-1003-50U | Mouse recombinant Endocan / ESM-1 50 kDa (50 µg) | Bioassay, WB | 50 µg |
| LIP-1102-10U | Mouse recombinant Endocan / ESM-1 20 kDa (10 µg) | Bioassay, WB | 10 µg |
| LIP-1102-50U | Mouse recombinant Endocan / ESM-1 20 kDa (50 µg) | Bioassay, WB | 50 µg |
| LIP-1104 | Standard Murine endocan | ELISA | 100 ng |
| LIP-1101 | Standard human Endocan | ELISA | 100 ng |
| LIDS-1001-10U | Dermatan sulfate chains from recombinant human endocan 10 µg | Bioassay | 10 µg |
| LIDS-1001-50U | Dermatan sulfate chains from recombinant human endocan 50 µg | Bioassay | 50 µg |