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【 GeneTex 2018年5/6月抗体百元试用 】
1134 人阅读发布时间：2018-05-09 15:33
【 GeneTex 2018年5/6月抗体百元试用 】
》》Post-translational modification蛋白质翻译后修饰
Post-translational modification (PTM) refers to the decoration of proteins through covalent addition of functional moieties, such as phosphate, acetyl, and methyl groups. As most PTMs are reversible, the functional flexibility of the proteome can be expanded and controlled in a temporal and cell type-specific manner to precisely contour signal transduction and gene expression in response to various stimuli. Therefore, understanding of PTM biology is crucial for the understanding of both normal and pathological physiology.
蛋白质翻译后修饰（PTM）是指通过共价键结合加入功能基团（如磷酸根，乙酰基和甲基）来装饰蛋白质。由于大多数PTM是可逆的，因此可以通过控制时间和细胞类型特异性等方式调节蛋白质组的功能灵活性，并得以了解细胞信号转导和基因表达对刺激的反应。因此，了解PTM生物学对理解正常和病理生理学至关重要。
》》Featured Products
| EGFR pTyr1068 antibody (GTX132810) | |
| Binding of EGFR to its ligands leads to receptor dimerization, autophosphorylation, and subsequent activation of signal transduction pathways that are involved in regulating cellular proliferation, differentiation, and survival. The GRB2 adaptor protein binds activated EGFR at phospho-Tyr1068 and triggers activation of Ras and its downstream ERK kinase pathway. EGFR与其配体的结合导致受体二聚化，自磷酸化，并随后激活参与调节细胞增殖，分化和存活的信号转导途径。GRB2衔接蛋白会在磷酸化Tyr1068处结合激活的EGFR并触发Ras及其下游ERK激酶信号转导途径。 |
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| EGFR pTyr1173 antibody (GTX133437) | |
| Phosphorylated Tyr1148 and Tyr1173 of activated EGFR are binding sites of Shc, SH2-containing scaffold protein. Shc binding directly regulates EGFR-induced activation of the JNK signaling pathway and indirectly activates the MAP kinase signaling pathway. EGFR的磷酸化位点Tyr1148和Tyr1173是与Shc支架蛋白的结合位点。Shc结合直接调节并活化EGFR诱导的JNK信号传导途径，并间接激活MAPK激酶信号传导途径。 |
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EGFR pTyr845 antibody (GTX133600) |
| Phosphorylation of EGF receptor (EGFR) by c-Src at Tyr845 in the kinase domain is implicated in stabilizing the activation loop, maintaining the active state enzyme, and providing a binding surface for substrate proteins. EGFR Tyr845 phosphorylation can also be used as a diagnostic marker of cancer treatments. c-Src可磷酸化EGFR激酶结构域中的Tyr845位点，此处的磷酸化可稳定EGFR活化环、维持EGFR激酶活性状态，并为底物蛋白质提供结合表面。EGFR Tyr845磷酸化也可以用作癌症治疗的诊断标志物。 |
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| ATM pSer1981 (GTX132146) | |
| Ataxia telangiectasia mutated kinase (ATM) is a cell cycle checkpoint serine/threonine kinase that promotes genome maintenance. Activation of ATM by autophosphorylation on Ser1981 occurs in response to DNA double-strand breaks. ATM丝氨酸/苏氨酸激酶是保持基因组稳定的细胞周期检查点重要蛋白质之一。当细胞发生DNA双链断裂时，可通过对Ser1981进行自磷酸化来激活ATM及下游DNA修补机制。 |
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| ATR pSer1989 (GTX128145) | |
| The ataxia telangiectasia and Rad3-related (ATR) serine/threonine kinase is a master checkpoint regulator. Phosphorylation of ATR at Thr1989 occurs in response to DNA single-strand damage and is crucial for ATR activation and ATR-mediated signaling. ATR丝氨酸/苏氨酸激酶是一个主要的细胞周期检查点调节因子，ATR Thr1989的磷酸化作用是响应DNA单链损伤而发生的，并且对于ATR活化和ATR介导的信号传导至关重要。 |
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p53 pSer15 antibody (GTX132995) |
| DNA damage induces phosphorylation of tumor suppressor p53 at Ser15 by ATM and ATR, leads to a reduced interaction between p53 and its negative regulator, the oncoprotein MDM2. Without MDM2-stimulated degradation, both the accumulation and activation of p53 were promoted in response to DNA damage. The activation of p53 can lead to either cell cycle arrest and DNA repair, or apoptosis. DNA损伤可通过ATM和ATR诱导p53肿瘤抑制蛋白Ser15位点的磷酸化，导致p53与其负调节物MDM2之间的相互作用减弱。没有MDM2刺激的降解，p53在细胞中的积累和激活都可促进细胞对DNA损伤的反应。p53的激活可导致细胞周期停滞、DNA修复、或细胞凋亡。 |
| Cat. No. | Product Name | Application | Validation |
| GTX132146 | ATM (phospho Ser1981) antibody | WB | Orthogonal |
| GTX128145 | ATR (phospho Thr1989) antibody | ICC/IF, IHC-P, IP, WB | Orthogonal|Comparison |
| GTX133980 | c-Abl (phospho Tyr245) antibody | WB | Orthogonal |
| GTX133862 | CDK2 (phospho Thr160) antibody | WB | KO/KD|Orthogonal |
| GTX132204 | Chk2 (phospho Thr68) antibody | WB | KO/KD|Orthogonal |
| GTX132810 | EGFR (phospho Tyr1068) antibody | ICC/IF, IHC-P, WB | Orthogonal |
| GTX133437 | EGFR (phospho Tyr1173) antibody | ICC/IF, WB | Orthogonal |
| GTX133600 | EGFR (phospho Tyr845) antibody | ICC/IF, WB, IHC-P | Orthogonal |
| GTX133429 | EGFR (phospho Tyr992) antibody | ICC/IF, WB | Orthogonal |
| GTX133445 | Her2 / ErbB2 (phospho Tyr1221/Tyr1222) antibody | WB, IHC-P | Orthogonal |
| GTX634421 | HSP27 (phospho Ser82) antibody [GT357] | WB | Orthogonal |
| GTX133883 | NBS1 (phospho Ser343) antibody | WB | Orthogonal |
| GTX132995 | p53 (phospho Ser15) antibody | ICC/IF, WB | Orthogonal |
| GTX634168 | p53 (phospho Ser46) antibody [GT1018] | ICC/IF, WB | Orthogonal |
| GTX133940 | PYK2 (phospho Tyr402) antibody | WB | Orthogonal |
| GTX133614 | SMAD2 (phospho Ser465/Ser467) antibody | WB | Orthogonal |
| GTX133464 | STAT3 (phospho Tyr705) antibody | WB | Orthogonal |
| GTX133947 | STAT5A (phospho Tyr694) antibody | WB | Orthogonal |
| GTX132660 | ULK1 (phospho Ser555) antibody | WB | Orthogonal |
| GTX132654 | ULK1 (phospho Ser758) antibody | WB | Orthogonal |
》》New Product
| Cat. No. | Product Name | Application | Validation |
| GTX131311 | Alpha fetoprotein / AFP antibody | WB | |
| GTX634415 | ARG2 antibody [GT11111] | IHC-P, WB | |
| GTX634200 | Arginase 1 antibody [GT825] | IHC-P, WB | Overexpression |
| GTX134510 | beta Amyloid (1-42) antibody – Conformation Specific | Dot, IHC-P | |
| GTX634534 | CrkL antibody [GT466] | WB | |
| GTX634420 | Cyclin A2 antibody [GT2547] | ICC/IF, WB | |
| GTX634347 | Cyclin D1 antibody [GT8912] | WB | |
| GTX634198 | Cystatin A antibody [GT2264] | WB | |
| GTX634187 | Cytochrome C antibody [GT1711] | WB | |
| GTX634409 | Cytokeratin 14 antibody [GT985] | WB | |
| GTX634308 | Cytokeratin 5 antibody [GT1486] | WB | |
| GTX628887 | EGFR antibody [GT133] | ICC/IF, IHC-P, IP, WB | KO/KD |
| GTX133269 | GABA B Receptor 2 antibody | WB | |
| GTX125897 | Galectin 3 antibody | ELISA, IHC-P, WB | KO/KD|Overexpression |
| GTX100509 | Her2 / ErbB2 antibody | IHC-P, WB | |
| GTX106585 | HN1 antibody | ELISA, WB | KO/KD |
| GTX113753 | IDO1 antibody | WB | Comparison |
| GTX634336 | LAMP1 antibody [GT25212] | ICC/IF, WB, IHC-P | |
| GTX634455 | nNOS antibody [GT5978] | WB | |
| GTX132732 | OLIG2 antibody | ICC/IF, IHC-Fr, IHC-P, WB | |
| GTX130453 | PKC alpha antibody | ICC/IF, IHC-Fr, WB | |
| GTX634291 | PSD95 antibody [GT1234] | ICC/IF, WB | |
| GTX133192 | PTEN (phospho Ser380) antibody | WB | Orthogonal |
| GTX130887 | PYK2 antibody | ICC/IF, IHC-P, IP, WB | |
| GTX133795 | RANK antibody | WB | Orthogonal |
| GTX134106 | SOX10 antibody | WB | |
| GTX131631 | VAPB antibody | WB | Orthogonal |
| GTX634535 | Vinculin antibody [GT3210] | WB | |
| GTX122157 | XBP1 antibody | ICC/IF, WB | Orthogonal |
| GTX634484 | ZAP70 (phospho Tyr319) / Syk (phospho Tyr352) antibody [GT1686] | WB | Orthogonal |
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