ENZO Y27632 . Dihydrochloride

782 人阅读发布时间：2015-05-26 09:09

27632是一种具有细胞渗透性的ROCK抑制剂，能选择性的抑制ROCK1(p160ROCK)和ROCK2。

CAS： 129830-38-2
纯度：>98%
保存：-20 °C避光保存。

货号	产品名称	规格	纯度	品牌
ALX-270-333-M025	Y-27632 . dihydrochloride	25 mg	>98%	ENZO(美国)
ALX-270-333-M005	Y-27632 . dihydrochloride	5 mg	>98%	ENZO(美国)
ALX-270-333-M001	Y-27632 . dihydrochloride	1 mg	>98%	ENZO(美国)

文献引用
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1. The effect of ROCK on TNF-α-induced CXCL8 secretion by intestinal epithelial cell lines is mediated
through MKK4 and JNK signaling: A.C. Perey, et al.; Cell Immunol. 293, 80 (2015), Application(s): Cell
Culture, Abstract;
2. Dissecting the roles of ROCK isoforms in stress-induced cell detachment. : J. Shi, et al. ; Cell Cycle
12, 1492,1500 (2013),Abstract;
3. Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment: J. Shi, et al.; Cell Death Dis.
4, e483 (2013),Abstract; Full Text;
4. Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells. : FA. Suprynowicz,
et al. ; PNAS 109, 20035,20040 (2012), Abstract;
5. ROCK Inhibitor and Feeder Cells Induce the Conditional Reprogramming of Epithelial Cells : X. Liu,
et al.;Am. J. Pathol. 180, 599,607 (2012), Abstract;
6. Use of reprogrammed cells to identify therapy for respiratory papillomatosis. : H. Yuan, et al. ; N Engl
J Med 367, 1220,1227 (2012), Abstract;
7. Small molecule inhibition of cytoskeletal dynamics in melanoma tumors results in altered transcriptional
expression patterns of key genes involved in tumor initiation and progression: C. Spencer, et al.; Cancer
Genom. Proteom. 8, 77 (2011), Abstract;
8. Effects of rho-kinase inhibition on pulmonary hypertension, lung growth, and structure in neonatal rats
chronically exposed to hypoxia. : AJ. Ziino, et al.; Pediatr Res. 67, 177,82 (2010), Abstract;
9. The proline-rich region of HIV-1 Nef affects CXCR4-mediated chemotaxis in Jurkat T cells: C.M. Lee, et al.;
     Viral Immunol. 21, 347 (2008), Abstract;
10. A Rho-kinase inhibitor, Y-27632, reduces cholinergic contraction but not neurotransmitter release: L.
   Fernandes, et al.; Eur. J. Pharmacol. 550, 155 (2006), Abstract;
11. Molecular characterization of the effects of Y-27632: H. Darenfed, et al.; Cell Motil. Cytoskeleton (2006),
   Abstract;
12. Rho-kinase inhibitor, Y-27632, has an antinociceptive effect in mice: K. Buyukafsar, et al.; Eur. J. Pharmacol.
541, 49 (2006),Abstract;
13. Structural basis for induced-fit binding of Rho-kinase to the inhibitor Y-27632: H. Yamaguchi, et al.; J. Biochem
     (Tokyo) 140, 305 (2006), Abstract;
14. Preventive effect of Y-27632, a selective Rho-kinase inhibitor, on ischemia/reperfusion-induced acute renal
     failure in rats: K. Teraishi, et al.; Eur. J. Pharmacol. 505, 205 (2004), Abstract;
15. Comparison of effects of Y-27632 and Isoproterenol on release of cytokines from human peripheral T cells:
     M. Aihara, et al.;Int. Immunopharmacol. 3, 1619 (2003), Abstract;
16. Inhibition of high K+-induced contraction by the ROCKs inhibitor Y-27632 in vascular smooth muscle: possible
     involvement of ROCKs in a signal transduction pathway: K. Sakamoto, et al.; J. Pharmacol. Sci. 92, 56 (2003),
     Abstract;
17. Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of
   selectivity:C. Breitenlechner, et al.; Structure 11, 1595 (2003), Abstract;
18. Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle
     cells: R.W. Rees, et al.; J. Urol. 170, 2517 (2003), Abstract;
19. Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway: K. Chitaley,
   et al.;Nat. Med. 7, 119 (2001), Abstract;
20. Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase
   inhibitor Y-27632: M. Takamura, et al.; Hepatology 33, 577 (2001), Abstract;
21. A p160ROCK-specific inhibitor, Y-27632, attenuates rat hepatic stellate cell growth: H. Iwamoto, et al.; J. Hepatol.
     32, 762 (2000), Abstract;
22. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases: T. Ishizaki, et al.;
Mol. Pharmacol. 57, 976 (2000), Abstract;
23. Specificity and mechanism of action of some commonly used protein kinase inhibitors: S.P. Davies, et al.;
Biochem. J. 351, 95 (2000), Abstract; Full Text
24. The effect of a Rho kinase inhibitor Y-27632 on superoxide production, aggregation and adhesion in human
polymorphonuclear leukocytes: A. Kawaguchi, et al.; Eur. J. Pharmacol. 403, 203 (2000), Abstract;
25. Use and properties of ROCK-specific inhibitor Y-27632: S. Narumiya, et al.; Meth. Enzymol. 325, 273 (2000),
      Abstract;
26. Y-27632, an inhibitor of rho-associated protein kinase, suppresses tumor cell invasion via regulation of focal
adhesion and focal adhesion kinase: F. Imamura, et al.; Jpn. J. Cancer Res. 91, 811 (2000), Abstract;
27. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase: M. Maekawa,
     et al.; Science 285, 895 (1999), Abstract;
28. Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in
neuroblastoma N1E-115 cells: M. Hirose, et al.; J. Cell Biol. 141, 1625 (1998), Abstract;
29. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension: M.
     Uehata, et al.; Nature389, 990 (1997), Abstract;

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