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919 人阅读发布时间：2014-05-07 17:05

Autophagy in human health and diseases.

Autophagy contributes to basal physiological homeostasis by regenerating metabolic precursors and clearing subcellular debris. Deregulation of this process has been implicated in many diseases, including cancer, metabolic and neuro degenerative disorders, and cardiovascular and pulmonary diseases. Shown above, the diagram reports the publication trends for the study of autophagy. However, clinical targeting of autophagy in human diseases is limited due to an obscure of how autophagy contributes to pathogenesis. Exploration of the mechanisms underlying this autophagy process may lead to the identification of new targets for clinical utility.

Please find the list below for a collection of autophagy molecules associated with human diseases.

For a complete catalogs of autophagy antibodies from GeneTex, visit our website at http://www.genetex.com/Web/News/Autophagy-332

Gene	Antibody	Association
BECN1	Beclin 1 antibody (GTX113039)	Breast, ovarian, and prostate cancers
UVRAG	UVRAG antibody (GTX129111)	Colon cancers
ATG1	ULK1 antibody (GTX128064)	Major autophagy initiator
ATG9	ATG9A antibody (GTX128427)	Assists in autophagosomal assembly
ATG5	ATG5 antibody (GTX113309)	Systemic lupus erythematosus, asthma, and lung dysfunction
ATG16L1	ATG16L1 antibody (GTX129098)	Chrohn's disease
NOD2	NOD2 antibody (GTX30694)	Chrohn's disease, and mycobacterium leprae infection
IRGM	IRGM antibody (GTX85038)	Chrohn's disease, and M. tuberculosis infection
LAMP2	LAMP2 antibody (GTX103214)	Danon's cardiomyopathy
PARK2	Parkin antibody (GTX25667)	Parkinson's disease, colon, lung and breast cancers
SQSTM1	SQSTM1 antibody (GTX100685)	Paget's disease
SMURF1	SMURF1 antibody (GTX89472)	Ulcerative colitis

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